RESEARCH

Research interests：

• Computational biology and bioinformatics
•  LncRNA identification and functional study
•  DNA methylation biomarkers in cancers and diseases
•  Noninvasive prenatal/cancer testing using plasma DNA analysis

• Data mining and visualization

Research highlights：

• Trace the tissue origin of the tumor through liquid biopsy
Sun et al. PNAS 2015 Oct 6; 112(40):E5503-12.

Plasma DNA Tissue Mapping

Sun et al. Genome Res 2019 Mar; 29(3):418-427.

Orientation-aware CfDNA Fragmentation analysis

• Molecular basis of cfDNA fragmentation

Sun et al. PNAS 2018 May 29; 115(22):E5106-E5114.

Size-tagged preferred ends

An et al. Nat Commun 2023 Jan 18; 14(1):287.

DNAm regulate cfDNA

• Interactions between YY1 transcription factor and lncRNAs

Zhou et al. Nat Commun 2015 Dec 11; 6:10026.

Linc-Yy1

Lu et al. EMBO J 2013 Oct 2; 32(19):2575-88.

Yy1 and Yam-1

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